The Yale Morph Server
© 1997-2003 Werner Krebs, Nat Echols, Mark Gerstein
[ citation | movie gallery | single-chain morph | RNA/DNA | multi-chain morph | FAQ list ]

This server will produce 2D and 3D animations of a plausible or semi-plausible pathway between two submitted protein subunit conformations. You may provide either a pair of PDB identifiers, or structures uploaded from your web browser, or a combination of the two to morph. This process may take anywhere from five minutes to half an hour to complete, depending on the size of the structures and the load on the server. You will receive notification by email when your morph is complete.

There are currently three forms of the server. The original version handles mutations, missing atoms and residues, and even homologous structures. This is the version to use if you are morphing single-chain structures taken directly from the PDB. We have recently implemented a new multi-chain morph server that allows morphing of large complexes, with mutations and/or deletions. An older version of this is still available if you want to morph nucleic acids; this will be phased out in the near future. Current constraints include:

All versions of the server use energy minimization to calculate the intermediate frames, which produces results that are usually much better than morphs made by simple linear interpolation, but still runs relatively quickly on modern hardware. A new method of interpolation using the program FRODA (Thorpe lab, ASU) is also available, and may be successful where the original fails to generate a reasonable interpolation.

In addition to being more flexible, the original server calculates a large number of statistics and performs sieve-fitting on the structures. All morphs are entered into the database for future analysis. You are welcome to download and use all output files and movies for your morph as long as you follow the citation guidelines.

Further information is available from a more detailed description of the server or the frequently asked questions list, as well as the original paper. You may also contact us by mailing "".

A number of third-party programs are essential to the server, including X-PLOR, CNS, PyMOL, AMPS, MolScript, and SAMPEG. You may obtain certain portions of the server (including a standalone CNS script for morphing) by arrangement with the authors.

Copyright 1995-2003, M. Gerstein and others
Last modified Feb. 7, 2003